Structure of Bovine CD46 Ectodomain

CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory family. Alongside its role in activation, CD46 involved many other processes, T-cell activation to reproduction. It also referred as pathogen magnet, because it used receptor by multiple bacteria and viruses. Bovine (bovCD46) particular bovine viral diarrhoea virus entry, an economically important disease cattle industries. This study presents X-ray crystallographic structure of extracellular region bovCD46, revealing four-short-consensus-repeat (SCR) similar that human CD46. SCR1-3 are arranged linearly, while SCR 4 has reduced interface angle, resulting hockey stick-like appearance. The reveals interaction site SCR1, which likely confer pestivirus specificity for their target host, Insights gained structural information on receptors, such could offer valuable guidance future control strategies.